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. Author manuscript; available in PMC: 2021 Mar 29.
Published in final edited form as: Transfusion. 2020 Nov 27;61(2):557–567. doi: 10.1111/trf.16200

FIGURE 3.

FIGURE 3

Cold storage induces ROS which can be prevented by addition of NAC to the PAS-E additive solution. (A) ROS generation of PRP pooled PLTs by flow cytometry (2′7′-dichlorofluorescein). Mean fluorescence intensity (MFI) is plotted. (B) Correlation and linear regression between increasing proton leak during RT storage and ROS generation. (C) Correlation and linear regression between increasing proton leak during cold storage and ROS generation. Total platelet storage bags tested N = 3. * P < .05; **P < .01; **P < .001 between RT/vehicle and cold/vehicle storage or between cold/vehicle and cold/NAC groups. ##, P < .01; ### P < .001 between cold - vehicle and cold - NAC.

N.S. = nonsignificant when compared to RT or cold by itself for storage between Days 7 and 14