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. Author manuscript; available in PMC: 2021 Mar 29.
Published in final edited form as: Mod Pathol. 2020 Jun 29;33(11):2295–2306. doi: 10.1038/s41379-020-0604-2

Fig. 3. Histologic features of malignant chondroblastoma giving rise to widespread metastases.

Fig. 3

a–d Are images of case 1, which gave rise to widespread metastases eventually leading to patient demise (Fig. 2). a This metastatic focus of malignant chondroblastoma exhibits permeative growth through bony trabeculae. b So-called “chicken-wire” calcifications are present multifocally in this tumor, as is common in conventional chondroblastoma. c This tumor exhibits frequent mitoses and greater cytologic atypia than conventional chondroblastoma. d Immunohistochemistry demonstrates nuclear positivity for H3K36M, which is essentially 100% specific for chondroblastoma.