Table 1.
Clinicopathologic characteristics of seven malignant chondroblastomas and four chondroblastoma-like osteosarcomas in this cohort.
| # | Consensus diagnosis | Original diagnosis | Primary site | Age (y) | Sex | Size (cm) | Mit/ 2 mm2 | Infiltrative borders | Necrosis | IHC status | Surgery | Margin Status | Additional treatment | Follow-up | Recurrence | Metastasis | Status |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Malignant CB | CB | Left third rib | 49 | M | NA | 15 | N | N | H3K36M: POS | RES | NEG | None | 26 y 5 m | Y | Y (Fig. 2) | DD |
| 2 | Malignant CB | CB-OS | Right talus | 48 | M | 4 | 1 | Y | N | H3K36M: NEG H3G34W: NEG | RES (AMP) | NEG | Chemotherapy | 7 y 2 m | N | N | DOC |
| 3 | Malignant CB | CB vs. CB-OS | Left anterior 4th rib | 29 | M | 4 | 3 | Y | N | H3K36M: POS | RES | NEG | 2 cycles of chemotherapy | 4 m | N | N | NED |
| 4 | Malignant CB | CB vs. Chondrosarcoma | Left anterior 4th rib | 55 | M | 6.4 | 2 | Y | N | H3K36M: POS | RES | NEG | None | 9 m | N | N | NED |
| 5 | Malignant CB | CB | Right acromion | 37 | M | 8.6 | 1; 3 (R) | NA | N | H3K36M: POS | CUR & CRYO | - | None | 5 y 5 m | Y | N | NED |
| 6 | Malignant CB | CB-OS | Right scapula | 65 | M | 13.5 | 2 | Y | Y (focal) | H3K36M: POS | RES | NEG | None | 1 y | N | N | NED |
| 7 | Malignant CB | CB | Right radial head | 57 | F | 3.5 | 3; 3 (R) | Y | N | H3K36M: POS | CUR & CRYO | - | None | 9 y 11 m | Y | N | NED |
| 8 | CB-OS | CB-OS | Right 9th rib | 19 | M | 6.5 | 3 | Y | Y | H3K36M: NEG H3G34W: NEG | RES | NEG | Chemotherapy | 1 y 9 m | N | N | NED |
| 9 | CB-OS | CB | Left scapula | 40 | F | NA | 2; 5 (R) | NA | Y | H3K36M: NEG H3G34W: NEG | RES | Unknown | Unknown | 21 y | N | Y (lung, skull, brain) | DD |
| 10 | CB-OS | Atypical osteochondral neoplasm; LG OS (R) | Proximal humerus | 23 | M | 10.9 (R) | 1; 2 (R) | N | Y (at fracture site) | H3K36M: NEG H3G34W: NEG | CUR | - | None | 16 y 4 m | Y | N | NED |
| 11 | CB-OS | CB-OS | C7 vertebra | 19 | F | 5.1 | 4 | Y | N | H3K36M: NEG H3G34W: NEG | RES | POS | Radiation | 1 y 5 m | Y | N | DD |
#
indicates case number, Mit mitoses, CB chondroblastoma, CB-OS chondroblastoma-like osteosarcoma, LG low-grade, OS osteosarcoma, R recurrence, NA not available, Y yes, N no, RES oncologic resection, AMP amputation, CUR curettage, CRYO cryotherapy, DD deceased from disease, DOC deceased from other causes, NED no evidence of disease.