. 2020 May 13;11(12):1726–1739. doi: 10.1021/acschemneuro.0c00244

Table 2. Predicted Pharmacokinetic Properties for the Three Selected PDE5 Inhibitors^a.

	miLogP	TPSA (Å²)	no. of atoms	MW	nON	nOHNH	no. of violations	no. of rotatable bonds	volume (Å³)
sildenafil	2.51	113.43	33	474.59	10	1	0	7	419.47
tadalafil	2.36	74.88	29	389.41	7	1	0	1	334.03
icariin	1.67	238.21	48	676.67	15	8	3	1	582.92

values for CNS drugs		≤140 or ≤60 (ideal)	–	≤400	≤7	≤3	–	–	–

Reference values for a successful CNS drug candidate are reported in the bottom line.

Table 2. Predicted Pharmacokinetic Properties for the Three Selected PDE5 Inhibitorsa.