Table 3. Properties of Oral EMs^a.

	oral organic EMs (n = 217)
	all, n (n = 217)	de novo, n (n = 108)	nature-inspired, n (n = 80)	natural, n (n = 29)
MW ≤ 500 Da	179	87	69	24
clogP ≤ 5	189	95	70	24
HBAs ≤ 10	188	96	68	24
HBDs ≤ 5	208	107	75	26
0 or 1 violations	186	94	67	25
2 or more violations	31	14	13	4

^aAbbreviations: clogP, calculated logP; HBA, hydrogen bond acceptor; HBD, hydrogen bond donor; MW, molecular weight; clogP were extracted using DrugBank²¹ or ChemSpider⁴² databases.