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. 2021 Feb 25;13(2):e13552. doi: 10.7759/cureus.13552

Figure 1. The different generations of CAR-T cells. (In addition to hematological malignancies, some fourth generation CAR T cells have also shown progress in the treatment of solid tumors, autoimmune diseases, and allergic diseases such as asthma. Antigen-specific Tregs and gene-edited T cell therapy have also shown encouraging results in controlling inflammation in allergic asthma.).

Figure 1

CD: cluster of differentiation; UniCAR: universal CAR-T cells; Treg: regulatory T cells; NFAT: nuclear factor of activated T cells; CD3ζ: cluster of differentiation three zeta; CAR: chimeric antigen receptor