Scheme 2.
Synthesis of compounds 11–14. Reagents and conditions: (i) Pd(OAc)2 (5 mol%), RuPhos (10 mol%), RBRn (1.2 equiv), CS2CO3 (3 equiv), Tol:H2O (4:1), 110 °C, 16 h; (ii) NH2OH·HCl, NaOAc, EtOH / H2O, rt, 16 h.
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.