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Scatterplot of relationship between change in Shannon diversity index of the stool microbiota versus the number of days with URTI symptoms in participants ≥45 years old given probiotics or placebo. Shannon diversity was measured in stool samples from study participants ≥45 years old at baseline and at end of the study (six months) using 16S rRNA gene profiling. Statistical analysis was performed using Pearson’s correlation analysis. Probiotic arm: n = 18; placebo arm: n= 13
