Table 3.
Logistic regression models of the composite endpoint of severe outcomes
| Unadjusted Model |
Adjusted Model I |
Adjusted Model II |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | P-value | aOR1 | 95% CI | P-value | aOR1 | 95% CI | P-value | |
| Demographics | |||||||||
| Age > 65 | 1.989 | 1.427–2.772 | <0.001 | 1.715 | 1.171–2.510 | 0.006 | 1.727 | 1.180–2.528 | 0.005 |
| BMI | 1.006 | 0.984–1.028 | 0.601 | ||||||
| Male Sex | 1.179 | 0.850–1.635 | 0.325 | 1.271 | 0.897–1.801 | 0.176 | 1.287 | 0.908–1.824 | 0.156 |
| Comorbidities | |||||||||
| DM | 1.346 | 0.967–1.873 | 0.078 | 1.050 | 0.709–1.555 | 0.807 | 1.053 | 0.711–1.559 | 0.796 |
| HTN | 1.654 | 1.137–2.408 | 0.009 | 1.129 | 0.693–1.840 | 0.627 | 1.121 | 0.694–1.842 | 0.622 |
| HLD | 1.556 | 1.119–2.165 | 0.009 | 1.373 | 0.935–2.015 | 0.105 | 1.370 | 0.933–2.011 | 0.109 |
| Heart Disease | 1.443 | 1.009–2.063 | 0.044 | 0.952 | 0.626–1.448 | 0.818 | 0.953 | 0.626–1.451 | 0.822 |
| Asthma | 1.274 | 0.798–2.032 | 0.310 | ||||||
| COPD | 1.314 | 0.768–2.249 | 0.318 | ||||||
| Kidney Disease | 1.472 | 1.035–2.093 | 0.031 | 1.122 | 0.740–1.700 | 0.588 | 1.101 | 0.724–1.674 | 0.652 |
| Cancer | 1.221 | 0.797–1.870 | 0.360 | ||||||
| Lab Findings | |||||||||
| Hemoglobin | 0.988 | 0.937–1.041 | 0.645 | ||||||
| Ferritin* | 1.000 | 1.000–1.000 | 0.001 | ||||||
| D-dimer* | 1.134 | 1.077–1.194 | <0.001 | ||||||
| WBC | 1.047 | 0.990–1.107 | 0.107 | ||||||
| CRP* | 1.096 | 1.066–1.128 | <0.001 | ||||||
| Platelet | 0.999 | 0.998–1.001 | 0.392 | ||||||
| ALT** | 1.003 | 0.999–1.007 | 0.096 | ||||||
| AST | 1.006 | 1.003–1.010 | 0.001 | 1.007 | 1.002–1.011 | 0.002 | 1.007 | 1.002–1.011 | 0.002 |
| Creatinine*** | 1.087 | 1.011–1.170 | 0.025 | ||||||
| Classifications | |||||||||
| Anemia (on admission) vs. none | 1.411 | 1.019–1.954 | 0.038 | 1.403 | 0.969–2.032 | 0.073 | |||
| Anemia Severity | |||||||||
| Mild vs. none | 1.383 | 0.872–2.200 | 0.168 | 1.297 | 0.792–2.125 | 0.301 | |||
| Mod-Sev vs. none | 1.441 | 1.045–1.985 | 0.026 | 1.532 | 1.048–2.230 | 0.028 | |||
Model I: Adjusted model for the association between anemia and composite endpoint of severe outcomes. Model II: Adjusted model for the association between different severities of anemia and composite endpoint of severe outcomes.1Adjusted Odds Ratio. *Variables with 20% or missing values were not included in the multivariable model due to too many missing values. **ALT was not included in multivariable models because of the high correlation with AST which appeared to be the highest predictive variable in bivariate analysis. ***Creatinine was not included in multivariable models because of the high correlation with CKD which appeared to be the highest predictive variable in bivariate analysis.