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Raloxifene reversed the cardiac dysfunction of pressure overload mice. (a, b) M-mode echocardiography images of mice measured at 4 (a) or 8 (b) weeks after TAC. (c, d) The increased mRNA expression of ANP (c) and BNP (d) in the murine hearts at 8 weeks were both reduced by raloxifene treatment. ∗p < 0.05; ∗∗∗p < 0.001.
