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Raloxifene decreased the phosphorylation of STAT3 and the expression of PHB2 in TAC murine heart. The p-STAT3 level, and protein expression of STAT3, PHB2 in murine hearts at 4 (a) and 8 (d) weeks by western blotting, and relative quantitation of p-STAT3 (b, e) and PHB2 (c, f) normalized by GAPDH (n = 3 per group). ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001.
