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. 2021 Mar 20;2021:6699054. doi: 10.1155/2021/6699054

Figure 6.

Figure 6

Raloxifene repressed the phosphorylation of STAT3 in hypertrophic H9c2 myoblasts. (a, b) The gentian violet staining showed H9c2 myoblasts manifested hypertrophy (a) and the relative cell area was increased (b) after incubation with IL-6 (25 ng/mL) for 48 h. (c–g) The sustained IL-6 incubation increased the protein expression of MYH7B (d), ANP (e), PHB2 (f), and the p-STAT3 level (g) in H9c2 myoblasts analyzed by western blotting (c). (h–j) Raloxifene decreased the level of p-STAT3 (i), and the expression of PHB2 (j) in H9c2 myoblasts induced by IL-6. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001, “ns” stands for “none significance”.