Table 1.
Multiplatform comparison of drug candidates A and B
| MS instrument | MS mode | Drug candidate A (n = 3) | Drug candidate B (n = 3) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Limit of detection (μg/g) | Coefficient of determination (R2) | Precision (% RSD at 25*/1250 μg/g) | Accuracy (% at 25*/1250 μg/g) | Limit of detection (μg/g) | Coefficient of determination (R2) | Precision (% RSD at 25*/1250 μg/g) | Accuracy (% at 25*/1250 μg/g) | ||
| Xevo Q-ToF | MS scan | 6.7 | 0.98 | 3.8/17.8 | 356/139 | 2.6 | 0.98 | 2.1/18.3 | 398/100 |
| Synapt Q-ToF | MS scan | 36.4 | 0.92 | <LOD/16.5 | <LOD/146 | 4.8 | 0.90 | 1.3/16.2 | 167/115 |
| HDMS | 225.3 | 0.90 | <LOD/17.0 | <LOD/103 | 8.0 | 0.94 | 0.1/15.3 | 621/64 | |
| HDMSE | 307.3 | 0.86 | <LOD/19.4 | <LOD/199 | 29.7 | 0.86 | <LOD/20.2 | <LOD/203 | |
| Xevo QqQ | MS scan | 569.4 | 0.93 | <LOD/17.7 | <LOD/70 | 119.1 | 0.95 | <LOD/37.5 | <LOD/73 |
| MRM** | 35.5 | 0.97 | <LOD/2.5 | <LOD/97 | 2.5 | 0.98 | 8.1/13.6 | 100/112 | |
*Note that for most of the MS modes, the QC at 25 μg/g level is below LOD
**The best instrument/mode is set in italics