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Quantification of drug candidates A and B in three ROIs in four dog liver tissues
| Concentration (μg/g) | ||||
|---|---|---|---|---|
| Tissue lesion | Connective tissue | Liver parenchyma | ||
| Dog liver 1 (65 mg/kg dosed B) | A | 526 ± 156 | 79 ± 27 | 242 ± 59 |
| B | 316 ± 115 | 172 ± 71 | 495 ± 78 | |
| Dog liver 2 (65 mg/kg dosed B) | A | 588 ± 126 | 136 ± 98 | 577 ± 227 |
| B | 100 ± 21 | 58 ± 84 | 269 ± 103 | |
| Dog liver 3 (65 mg/kg dosed A) | A | 2549 ± 673 | 2302 ± 966 | >ULOQ |
| B | ND | ND | ND | |
| Dog liver 4 (15 mg/kg dosed A) | A | 465 (n = 1) | 366 ± 28 (n = 2) | 480 ± 50 |
| B | ND | ND | ND | |
