Fig. 2.

Morphology of untreated and imatinib-treated S. mansoni. a Untreated control couple of adult S. mansoni worms with an overview of the major organs. As typical for schistosome couples, the male surrounded the female. b Imatinib (100 μmol/L) destroyed the gastrodermis (arrows) of male and female worms within 4 h treatment. Accumulation of cellular debris (*) was found in the intestinal lumen. c Imatinib (100 μmol/L) induced degradation of the female ovary as early as 24 h, and more severely after 48 h treatment (holes, #). io, immature oocytes; mo, mature oocytes; teg, tegument; scale bar, 100 μm (a) or 50 μm (b, c)