Skip to main content
. 2021 Jan 21;124(7):1301–1311. doi: 10.1038/s41416-020-01250-4

Fig. 3. EEF1A2 silencing inhibits tumour growth and metastasis in vivo.

Fig. 3

a Balb/c nude mice were subcutaneously injected with cells stably-silenced EEF1A2 (sh-EEF1A2_001) or control A549 cells (sh-CTR). Gross pathology of the subcutaneously xenograft immediately after resection. n = 8. b Tumour formation was monitored at the indicated intervals, and tumour weights were recorded. Data are shown as mean ± SEM; n = 8, two-tailed Student’s t-test. c The EEF1A2 expression level of the control and sh-EEF1A2_001 group. d Luciferase-labelled sh-CTR or sh-EEF1A2_001 A549 cells were intravenously injected into nude mice. Bioluminescence was examined after 8 weeks. The number of metastatic nodules in the lungs was shown as mean ± SEM (n = 5), using a two-tailed Student’s t-test. e, f Metastatic lung (e), and lymph nodes (f) in mice were presented and confirmed by Haematoxylin and Eosin staining (scale bar, 200 and 50 μm, respectively). *p < 0.05, **p < 0.01, and ***p < 0.001, NS no statistical significance.