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. 2021 Jan 21;124(7):1301–1311. doi: 10.1038/s41416-020-01250-4

Fig. 6. EEF1A2 regulates TGF-β/SMAD signalling based on HSP90AB1.

Fig. 6

a HSP90AB1 silencing inhibited the invasion potential of A549 cells induced by EEF1A2 overexpression. Data are shown as mean ± SEM; n = 3 independent experiments, two-tailed Student’s t-test. b A549 and PC9 cells were co-transfected with PCDH-EEF1A2, and si-HSP90AB1. The protein expression levels of HSP90AB1, EEF1A1, TβRI, TβRII, SMAD3, pSMAD3, N-cadherin and SLUG were detected using western blot analysis. c Overall survival according to Kaplan–Meier analysis showed the survival rate of LUAD patients with EEF1A2 overexpression, and HSP90AB1 overexpression separately or combined. d The ROC curves of EEF1A2 was combined with HSP90AB1 for the diagnosis of LUAD. (AUC = 0.8130, 95% CI: 0.7188–0.9072). *p < 0.05, **p < 0.01, and ***p < 0.001, NS no statistical significance.