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. 2021 Mar 29;11:7113. doi: 10.1038/s41598-021-86464-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of oesophagus microbiota alpha-diversity across groups. Tukey plots showing alpha-diversity for Chao1 (A and D), Shannon’s H (B and E) and inverse Simpson’s (C and F) indices. Comparison of control subjects, baseline and post-treatment EoE patients, and negative controls for each of the indices analyzed (A–C). Comparison of paired pre- and post-treatment samples divided by treatment for each of the indices analyzed (D-F). *p < 0.05, **p < 0.01. EoE: eosinophilic oesophagitis; EoE post-Tx: EoE patients after treatment; Neg control: negative controls for 16S amplification; FED: food elimination diet; PPI: proton pump inhibitors; STC: swallowed topical corticosteroids.