Table 3.

Differential abundance testing for predicted metabolic content and pathways.

	BH-adjusted p-values (FDR)
	EC 1.8.2	PWY.5022	PWY.6470	GLUTORN.PWY	ARGSYN.PWY
Controls vs. EoE baseline	ns	0.248	ns	0.129	0.241
Controls vs. post-FED	ns	0.175	ns	ns	ns
Controls vs. post-PPI	ns	0.190	ns	ns	ns
Controls vs. post-STC	ns	ns	ns	0.229	ns
Pre-STC vs. post-STC	0.082	ns	ns	ns	ns
Post-STC vs. post-FED	0.048	ns	0.155	ns	ns
Post-STC vs. post-PPI	0.060	ns	ns	ns	ns

Only reactions (Enzyme Commision number; EC) and pathways (PWY) with at least one significant difference between groups according to adjusted p < 0.1 and p < 0.25 (Benjamini–Hochberg correction), respectively, are shown. BH: Benjamini–Hochberg correction; FDR: false discovery rate; EC 1.8.2: sulphur-cytochrome oxidoreductases; PWY.5022: 4-aminobutanoate degradation; PWY.6470: peptidoglycan biosynthesis V (β-lactam resistance); GLUTORN.PWY: L-ornithine biosynthesis I; ARGSYN.PWY: L-arginine biosynthesis II; EoE: eosinophilic oesophagitis; FED: food-elimination diet; PPI: proton pump inhibitors; STC: swallowed topical corticosteroids; ns: not significant (p > 0.1 for EC and p > 0.25 for PWY).