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. 2021 Mar 29;11:7117. doi: 10.1038/s41598-021-86514-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Urolithin A suppressed the inflammatory miRNA expression in LPS-stimulated murine BMDMs. Murine BMDMs were stimulated by 1 µg/ml of LPS in the presence or absence of UA (25 µM or 50 µM). The expression of miR-9 (a), miR-10 (b), miR-99b (c), miR.146a (d) and miR-155 (e) over 5S rRNA was evaluated in stimulated BMDMs after 72 h. The unstimulated and untreated BMDMs were used as control. BMDMs treated with DMSO were used as negative control. Arithmetic means ± SEM from seven independent experiments are depicted. One way ANOVA was used and *(p < 0.05), **(P 0.01), ***(p < 0.001), and ****(p < 0.0001) indicate statistically significant differences compared to control. ++(P 0.01), +++(p < 0.001), and ++++ (p < 0.0001) indicate statistically significant differences compared to LPS. Abbreviations: DMSO, dimethyl sulfoxide; UA, urolithin A; LPS, lipopolysaccharides; miR, micro RNA.