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. 2021 Mar 29;11:7025. doi: 10.1038/s41598-021-86601-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of the induction of heat shock proteins (HSP) on the expression of inflammatory cytokines in the aorta in ApoE^−/− mice. (A) Interleukin 6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) mRNA expression levels in the aorta after geranylgeranylacetone (GGA) administration. 10-week-old ApoE^−/− mice, evidencing the formation of atheromas, were administered vehicle or GGA (500 mg/kg/day) for 24 h. Then, total RNA was extracted from the aorta. (B) IL-6 and TNF-alpha mRNA expression levels in the aorta after heat shock treatment. 10-week-old ApoE^−/− mice, demonstrating the formation of atheromas, were treated in a 30 °C (control) or 41 °C (heat shock) warm bath for 30 min. After 24 h, total RNA was extracted from the aorta. Each bar represents the mean ± standard deviation (SD). Significant differences are marked on the chart (*p < 0.05; **p < 0.01). n = 5–8 mice per group.