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. 2021 Jan 21;124(7):1249–1259. doi: 10.1038/s41416-020-01257-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Pearson correlation analysis of cell line response to Neratinib, Lapatinib, and Tucatinib with gene expression levels in 99 of 115 cancer cell lines. Correlations for each respective drug (Neratinib—blue dots, Lapatinib—orange dots, tucatinib—green dot) were compared to 168 reference compounds (grey dots). These correlations were normalised to a Σ-score. A negative score indicates a higher gene expression correlates to sensitivity to the drug. A positive score represents high gene expression correlates to insensitivity. The top 20 clinically actionable genes significantly associated with a sensitivity and b resistance are shown. Correlations of the CCLE microarray gene expression data set were validated using CCLE RNAseq, COSMIC, and Genentech mRNA expression databases. Non-black genes are considered validated, i.e. significantly correlated in at least two out of three additional gene expression data sets. In addition, genes in red and light green are validated for three out of three and two out of three HER2 TKIs, respectively. Genes in purple are validated only for the corresponding compound.