Table 4.
Associations of HT-SARS-CoV-2 with immune process relevant genes in PBMC, B cells, and T cells.
| Immune cells | PBMC | B cell | CD4+ T cell | CD8+ T cell | |||||
|---|---|---|---|---|---|---|---|---|---|
| Gene A | Gene B | R | P | R | P | R | P | R | P |
| ACE2 | TMPRSS2 | 0.194749 | 0.00E+00 | 0.563 | 2.31E-04 | 0.207922 | 1.00E-06 | 0.397018 | 1.00E-06 |
| TMPRSS2 | FURIN | 0.052281 | 0.021933 | 0.584 | 0.000117 | 0.015903 | 7.10E-01 | −0.031942 | 6.99E-01 |
| ACE2 | DPP4 | 0.040884 | 7.32E-02 | 0.316 | 5.30E-02 | 0.072992 | 8.69E-02 | −0.141403 | 8.54E-02 |
| TMPRSS2 | DPP4 | 0.040639 | 0.074956 | 0.352 | 3.00E-02 | −0.015323 | 7.20E-01 | −0.151717 | 6.47E-02 |
| FURIN | DPP4 | −0.035395 | 1.21E-01 | 0.301 | 6.60E-02 | 0.470333 | 0.00E+00 | 0.377543 | 2.00E-06 |
| ACE2 | ADAM17 | −0.214355 | 0.00E+00 | −0.488 | 1.86E-03 | −0.00236 | 9.56E-01 | −0.172781 | 3.51E-02 |
| FURIN | ADAM17 | 0.282705 | 0.00E+00 | −0.488 | 1.90E-03 | 0.088845 | 0.037081 | 0.271443 | 8.12E-04 |
| ACE2 | GP2 | 0.231479 | 0.00E+00 | 0.693 | 0.00000145 | 0.362058 | 0 | 0.329296 | 4.10E-05 |
| FURIN | GP2 | 0.01108 | 6.27E-01 | 0.519 | 0.000848 | −0.073753 | 0.08369 | 0.07534 | 3.61E-01 |
| ACE2 | TFRC | 0.188254 | 0.00E+00 | −0.393 | 0.015 | 0.028397 | 0.505932 | 0.094183 | 2.53E-01 |
| FURIN | TFRC | 0.158378 | 0.00E+00 | −0.512 | 0.00102 | 0.395723 | 0 | 0.331861 | 3.60E-05 |
| TMPRSS2 | CTSL | 0.096595 | 2.20E-05 | −0.047 | 7.81E-01 | 0.033176 | 4.37E-01 | −0.067532 | 4.13E-01 |
| FURIN | CTSL | 0.134294 | 0.00E+00 | 0.138 | 4.10E-01 | −0.119595 | 4.94E-03 | 0.252604 | 1.88E-03 |
| TMPRSS2 | MYC | 0.076205 | 8.30E-04 | −0.614 | 4.12E-05 | 0.09934 | 1.97E-02 | −0.023417 | 7.77E-01 |
| FURIN | MYC | −0.216085 | 0.00E+00 | −0.484 | 2.08E-03 | 0.272609 | 0.00E+00 | 0.054391 | 5.10E-01 |
| TMPRSS2 | AKT1 | 0.04259 | 6.20E-02 | 0.305 | 6.30E-02 | 0.062252 | 1.44E-01 | 0.082334 | 3.18E-01 |
| FURIN | AKT1 | 0.282536 | 0.00E+00 | 0.256 | 1.20E-01 | 0.412729 | 0.00E+00 | 0.206321 | 1.16E-02 |
| TMPRSS2 | SRC | 0.118741 | 0.00E+00 | 0.642 | 1.37E-05 | 0.012309 | 7.73E-01 | 0.161731 | 4.88E-02 |
| FURIN | SRC | −0.005434 | 8.12E-01 | 0.578 | 1.44E-04 | 0.114058 | 7.36E-03 | −0.036473 | 6.59E-01 |
| TMPRSS2 | GAPDH | 0.166781 | 0.00E+00 | No data | 0.111217 | 8.98E-03 | 0.096452 | 2.42E-01 | |
| FURIN | GAPDH | −0.104979 | 0.000004 | No data | 0.392612 | 0 | 0.05329 | 0.518622 | |
Correlation of HT-SARS-CoV-2 with immune process relevant genes was performed by ImmuCo using data sets obtained from PBMC, B cells, and T cells. Data are presented as correlation values (R), including the statistical significance (P).