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. 2021 Mar 16;8:625347. doi: 10.3389/fvets.2021.625347

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Copyright © 2021 Quiroga, Alarcón, Manosalva, Teuber, Taubert, Hermosilla, Hidalgo, Carretta and Burgos.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HIF-1 is involved in the D-lactate-induced overexpression of inflammation- and metabolism-associated genes in bFLS. bFLS were preincubated with 40 μM YC-1 and then stimulated with 5 mM D-lactate for 6 h. The relative mRNA expression levels of (A) IL-6, (C) HIF-1α, (D) Glut-1, and (E) PDK-1 are shown. (B) IL-6 levels in conditioned media were measured by ELISA. bTNF-α was used as the positive control. Each bar represents the mean ± SEM, n = 5. *p < 0.05; **p < 0.01; n.s., not significant.