Table 3.
In vitro anticancer and anti-aromatase activities of citrus peel extracts and the isolated compounds.
| The tested samples | IC50 values (µg/mL) ± SD | |||
|---|---|---|---|---|
| Cytotoxic effect on MCF7 | Cytotoxic effect on T47D | Cytotoxic effect on HFB4 | Aromatase inhibition | |
| Valencia orange (sefi) | 12.1 ± 2.30 | 24.4 ± 3.27 | 197.0 ± 5.23 | ND |
| Common Baladi orange | ND | ND | ND | ND |
| Navel orange (sorra) | ND | ND | ND | ND |
| Bitter orange | 12.5 ± 2.77 | 17.9 ± 3.11 | 295.0 ± 22.15 | ND |
| Mandarin | ND | ND | ND | ND |
| Ponkan tangarine | ND | ND | ND | ND |
| Dancy tangerine | 14.5 ± 1.87 | 12.5 ± 2.26 | 200.0 ± 6.77 | ND |
| Egyptian lime | 5.5 ± 0.49 | 7.9 ± 1.22 | 62.0 ± 9.83 | ND |
| Grapefruit Duncan | 4.9 ± 0.93 | 5.9 ± 0.89 | 64.0 ± 8.66 | ND |
| Grapefruit star ruby red | ND | ND | ND | ND |
| Standard Ketoconazole | ND | ND | ND | 2.0 ± 0.15 |
| C1 | – | – | – | ND |
| C2 | 2.11 ± 0.71 | 1.81 ± 0.28 | – | 0.23 ± 0.01 |
| C3 | – | – | – | ND |
| C4 | 1.12 ± 0.09 | 1.93 ± 0.07 | – | 1.615 ± 0.05 |
| C5 | – | – | – | ND |
| C6 | 4.96 ± 0.89 | 3.53 ± 0.19 | – | ND |
| C7 | – | – | – | ND |
| C8 | 2.00 ± 0.98 | 3.63 ± 0.10 | – | 1.894 ± 0.07 |
ND not done.
(−) no activity in a concentration up to 50 µg/mL.