Table 1.
Potential inhibitors of inflammasome-dependent coagulation.
| Mechanism | Function | Name | Usage | Model | References |
|---|---|---|---|---|---|
| Reduce Ca2+ influx | Calcium chelator | BAPTA-AM | Up to 10 μM | PMs WT or ITPR1-KD BMDMs/THP1 | (56, 62) |
| Ethylenediaminetetraacetic acid (EDTA) | Up to 600 μM | PMs | (56) | ||
| ER stress inhibitor | Tauroursodeoxycholic acid (TUDCA) | 200 mg/kg | WT or Tmem173−/− mice | (62) | |
| 50 μM | THP1 | (62) | |||
| 4-phenyl butyric acid (4PBA) | 1 mM | THP1 | (62) | ||
| D-myo-inositol 1,4,5-trisphosphate (IP3) receptor antagonist | 2-Aminoethoxydiphenylborane (2-APB) | 20 mg/kg | WT or Tmem173−/− mice | (62) | |
| TMEM16F inhibitor | Tannic acid (TA) | NA | PMs | (56) | |
| Niflumic acid (NFA) | NA | PMs | (56) | ||
| PLCG1 inhibitor | U73122 | 10 μM | THP1 | (62) | |
| 30 mg/kg | WT or Gsdmd105N/105N mice | (62) | |||
| Inhibit caspase 8 cleavage | Caspase 8 inhibitor | Z-IETD-FMK | 20 μM | WT or Casp1−/−Casp11−/− BMDMs | (62) |
| Prevent NLRP3 oligomerization | NLRP3 inhibitor | MCC950 | 50 mg/kg | Rat | (25) |
| Delete in vivo macrophage | Macrophage remover | Clodronate liposomes | 40 mg/kg | Mice | (30, 56) |
| Neutralize HMGB1 | HMGB1 antibody | 2G7 | 160 μg/mouse | Mice | (56) |
| Prevent membrane rupture | Osmoprotectant | Glycine | 5 mM | BMDMs | (30) |