TABLE 3.

Post-translational modification of non-ribosomal peptide synthetases (NRPSs), PKSs, long acyl-CoA synthases, and other antibiotic biosynthetic enzymes.

Enzyme	Product	Type of modification	References
NRPS	Non ribosomal peptide (unknown structure)	Acetylation	Xu J. Y. et al., 2018
Acyl-CoA synthase	Medium and long fatty-acyl-CoA	Acetylation	Liao et al., 2014
DesD	Desferroxiamine	Acetylation	Liao et al., 2014
FrbH decarboxylase/aminotransferase	Phosphinic acid-derived compound	Acetylation	Liao et al., 2014
StrM deoxysugar epimerase	Streptomycin	Acetylation	Ishigaki et al., 2017;
PPTases of ACP, PCP domains of NRPSs PKSs and FASs domains*	Holoenzymes NRPSs, PKSs y FASs	Pantetheinylation	Wang et al., 2016; Ordóñez-Robles et al., 2017

*There are numerous PPTases that modify enzymes of the biosynthesis of secondary metabolites.