FIGURE 1.

Infection route, spreading and shedding at different organs of the body and tissue-specific distribution of AQPs. The roles of AQPs in non-infectious diseases such as different cancers and tumors, cerebral edema and ischemic stroke, obesity, renal and skin diseases, and cataracts have been widely studied. At least 10 AQPs of different organs are associated with bacterial, viral, and parasitic infections. Expressions of AQPs in infectious diseases are summarized in Table 2 of the current review.