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. 2021 Mar 16;12:643449. doi: 10.3389/fmicb.2021.643449

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Copyright © 2021 Chen, He, Li, Zou, Si, Guo, Yu, Li, Wang, Chan and Shi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Integrated analysis of skin microbes and plasma metabolites. (A) Spearman correlation analysis between significantly altered skin microbes and significantly changed plasma metabolites in the healthy control group. Red, positive correlation; blue, negative correlation. *p < 0.05. (B) Spearman correlation analysis between significantly altered skin microbes and significantly changed plasma metabolites in the psoriasis group. Red, positive correlation; blue, negative correlation. *p < 0.05. (C) Spearman correlation network between significantly altered skin microbes and significantly changed plasma metabolites in all samples from both groups. The purple circle represents the skin microbiota, and the cyan diamond represents plasma metabolites. Red line, positive correlation; blue line, negative correlation. Only the correlations with p < 0.05 are shown. **p < 0.01.