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. 2021 Mar 16;12:623973. doi: 10.3389/fimmu.2021.623973

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Copyright © 2021 Loussouarn, Pers, Bony, Jorgensen and Noël

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Extracellular vesicle-mediated delivery of miRNAs into recipient cells. Mesenchymal stromal cell (MSC) released extracellular vesicles (EVs) that contain miRNAs (EV-miRNAs). MiRNAs are taken up by the recipient cells via different mechanisms and act in the cytosol by interacting with targets. Akt1, protein kinase B; CamKII, calmodulin-dependent protein kinase II; DRP1, Dynamin-related protein 1; Fa-CoA. Fatty acid coenzyme A; HADHB, Hydroxyacyl-CoA Dehydrogenase Trifunctional Multienzyme Complex Subunit Beta; KEAP1, Kelch-like ECH-associated protein 1; Nrf2, NF-E2 p45-related factor 2; OXPHOS, oxidative phosphorylation; PDH, Pyruvate dehydrogenase; PTEN, Phosphatase and tensin homolog; ROS, reactive oxygen species; SFRP, secreted frizzled-related protein; SIRT, sirtuin; SOD, superoxydes dismutase; STAT, signal transducer and activator of transcription; TCA, tricarboxylic acid cycle; Wnt, wingless.