Table 5.
Prognostic factors for therapeutic outcomes of patients lacking prognosis-defining genomic abnormalities in CCLG-ALL-2008 cohort.
| Overall Survival | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Univariate Cox’s regression | Multivariate Cox’s regression | ||||||||
| Variate | Category | OR | 95% CI | p value | OR | 95% CI | p value | ||
| Lower | Upper | Lower | Upper | ||||||
| CD123 | Negative | 0.001 | 0.030 | ||||||
| High | 0.241 | 0.110 | 0.530 | 0.000 | 0.448 | 0.144 | 1.389 | 0.164 | |
| Age | <1 | 0.004 | 0.018 | ||||||
| 1–10 | 0.045 | 0.006 | 0.355 | 0.003 | 0.026 | 0.002 | 0.341 | 0.005 | |
| >10 | 0.099 | 0.011 | 0.855 | 0.036 | 0.039 | 0.002 | 0.669 | 0.025 | |
| WBC (×109/L) | WBC<20 | 0.046 | 0.828 | ||||||
| 50<WBC<100 | 2.915 | 1.156 | 7.350 | 0.023 | 1.459 | 0.349 | 6.099 | 0.605 | |
| WBC>100 | 3.625 | 1.067 | 12.335 | 0.039 | 2.034 | 0.379 | 10.921 | 0.408 | |
| Risk group | LR | 0.036 | 0.801 | ||||||
| IR | 2.398 | 0.871 | 6.601 | 0.090 | 0.995 | 0.305 | 3.247 | 0.994 | |
| HR | 3.866 | 1.376 | 10.863 | 0.010 | 1.389 | 0.362 | 5.336 | 0.632 | |
| Day 33 MRD level | 0.01–1% | 2.123 | 0.918 | 4.905 | 0.078 | 2.039 | 0.776 | 5.358 | 0.148 |
| Event-free Survival | |||||||||
| Univariate Cox’s regression | Multivariate Cox’s regression | ||||||||
| Variate | Category | OR | 95% CI | p value | OR | 95% CI | p value | ||
| Lower | Upper | Lower | Upper | ||||||
| CD123 | Negative | 0.001 | 0.044 | ||||||
| High | 0.331 | 0.183 | 0.599 | 0.000 | 0.342 | 0.135 | 0.868 | 0.024 | |
| Age | <1 | 0.066 | 0.880 | 0.282 | 2.747 | 0.826 | |||
| 1–10 | 0.125 | 0.017 | 0.924 | 0.042 | |||||
| Steroid resistance | 2.247 | 1.187 | 4.253 | 0.013 | 1.051 | 0.331 | 3.336 | 0.933 | |
| Risk group | LR | 0.000 | 0.590 | ||||||
| HR | 4.024 | 1.921 | 8.429 | 0.000 | 1.556 | 0.422 | 5.744 | 0.507 | |
| Day 15 BM remission | M3 | 1.986 | 1.036 | 3.808 | 0.039 | 1.531 | 0.519 | 4.521 | 0.440 |
| Day 33 MRD level | <0.01% | 0.001 | 0.294 | ||||||
| 0.01–1% | 2.534 | 1.341 | 4.785 | 0.004 | 1.918 | 0.839 | 4.383 | 0.123 | |
| >1% | 5.955 | 1.969 | 18.008 | 0.002 | 1.401 | 0.228 | 8.602 | 0.716 | |
| Week 12 MRD level | >0.1% | 3.511 | 1,597 | 7.722 | 0.002 | 2.446 | 0.861 | 6.948 | 0.093 |
| Relapse-free Survival | |||||||||
| Univariate Cox’s regression | Multivariate Cox’s regression | ||||||||
| Variate | Category | OR | 95% CI | p value | OR | 95% CI | p value | ||
| Lower | Upper | Lower | Upper | ||||||
| CD123 | Negative | 0.000 | 0.007 | ||||||
| Low | 0.452 | 0.198 | 1.032 | 0.059 | 0.613 | 0.209 | 1.800 | 0.373 | |
| High | 0.219 | 0.108 | 0.443 | 0.000 | 0.226 | 0.085 | 0.599 | 0.003 | |
| Risk group | IR | 2.215 | 0.931 | 5.269 | 0.072 | 0.856 | 0.297 | 2.467 | 0.773 |
| Day 33 MRD level | <0.01% | 0.003 | 0.031 | ||||||
| 0.01–1% | 4.141 | 1.843 | 9.305 | 0.001 | 3.206 | 1.296 | 7.933 | 0.012 | |
| Week 12 MRD level | >0.1% | 3.013 | 1.226 | 7.404 | 0.016 | 2.694 | 0.858 | 8.461 | 0.090 |
Bold numbers represent that p value reaches statistical significance.