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. 2021 Mar 16;12:657424. doi: 10.3389/fimmu.2021.657424

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Copyright © 2021 Pedreño-Lopez, Rosen, Flores, Gorman, Voigt, Ricciardi, Crosno, Weisgrau, Parks, Lifson, Alter, Rakasz, Magnani, Martins and Watkins.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Characterization of Env-binding Abs from Mamu-B*17+ RMs at the time of first SIV challenge. Sera of immunized Mamu-B*17+ rapid controllers (in green) were compared to sera of non-controllers (in pink) prior to challenge at 1:500 dilution. (A) gp140-specific Ab subclass and isotype titers, and rhesus FcγRIIa/FcγRIIIa affinity were measured by Luminex. Mean log MFI for negative controls was 3.7. (B) gp140-specific responses for each of the three Ab effector functions measured: ADCP, ADCD, and NK degranulation. None of the differences between rapid controllers and non-controllers at the time of SIV challenge from both panels were statistically significant (p > 0.05 by Mann-Whitney U test).