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. 2021 Mar 16;11:637018. doi: 10.3389/fcimb.2021.637018

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Copyright © 2021 Chen, Cheng, Cai, Wei, Li, Liang, Zhang, Yu, Liu, Liu, Zhang, Wang and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Abundant ARGs in the pleural effusion microbiome. (A) Stacked bar plot of antibiotics resistant classes in the pleural effusion metagenome. (B) The 30 most abundant ARGs in the HA- and LA-SA type were displayed by heatmap. (C) Principal Coordinate Analysis. ARG composition is independent of microbiome community composition. (D) Diversity estimates of detected resistance features. Significant differences in Shannon diversity estimates of different resistance features of the CARD database inside the HA- and LA-SA type.