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. 2021 Mar 16;11:619346. doi: 10.3389/fonc.2021.619346

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Copyright © 2021 Chen, Hou, Zhao, Cai, Zhang, Li, Tang, Liu, Liu, Zhang, Yang, Gao, Yao, Zhu and Cao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Apoptosis of cells in each group at a qualitative level. (A) Flow cytometry analysis with Annexin V-PI staining was performed to evaluate the percentage of apoptotic cells in each group. (B) Histograms indicated the percentage of apoptotic cells in each group at 48 h after transfection. The percentage of apoptotic cells in the transfection experimental group was significantly increased compared with that of the controls. Data represented mean ± SD of three independent repeats (n = 3, *P < 0.05, ****P < 0.0001 respectively vs. the bland control and the negative control). ns, statistical significance exist. (C) Overexpression of miR-34a in XWLC-05 and YTMLC-90 cells could cause obvious characteristic features of apoptosis at 48 h posttransfection. The images were taken under the transmission electron microscope (magnifications: 10,000× and 12,000×, scale bar 2μm). Transfection, the pGCMV/EGFP-hsa-miR-34a plasmid transfection experimental group. Control, the blank control group.