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(A) Study workflow. (B) Lesion VOIs delineation illustrated in 2D (first row) and 3D (second row). The Vtc (green) is the tumor core; the Vpt (red) is the peritumor region at a given distance (2; 4; 6; 8; 10; 12; 14 mm) away from the tumor margin; the Vtc + Vpt (yellow) is the combination region of Vtc and Vpt. Vtc, volume of tumor core; Vpt, peripheral tumor regions; Vtc + Vpt, combination of Vtc and Vpt.
