Table 2.
Demographics of controls, Hashimoto’s thyroiditis (HT), PV patients and PF patients.
| Characteristic | Controls (n=65) | Hashimoto’s disease (n=22) | PV (n=66) | PF (n=32) | p value (PV vs. Controls) | p value (PF vs. Controls) | p value (PV vs. HT) | p value (PF vs. HT) |
|---|---|---|---|---|---|---|---|---|
| Age, year (mean ± SEM) | 52.39 ± 0.75 | 51.05 ± 1.78 | 51.65 ± 1.73 | 56.57 ± 2.03 | 0.86^ | 0.26^ | 0.808^ | 0.051^ |
| Gender, female/male | 39/26 | 11/11 | 36/30 | 18/14 | 0.597^ | 0.827^ | 0.807^ | 1.000^ |
| Disease duration (months, mean ± SEM) | 2.25 ± 0.25 | 6.54 ± 1.75 | ||||||
| Anti-TPO, IU/ml (mean ± SEM) | 28.62 ± 16.24 | 470.95 ± 76.35 | 46.44 ± 21.71 | 28.70 ± 14.68 | <0.0001# | 0.0023# | <0.0001# | <0.0001# |
| Positive anti-TPO, n (%) | 6 (9.23%) | 22 (100%) | 16 (24.24%) | 6 (18.75%) | 0.034^ | 0.2017^ | <0.0001^ | <0.0001^ |
| Anti-Tg, IU/ml (mean ± SEM) | 11.51 ± 5.43 | 209.05 ± 71.64 | 32.93 ± 12.31 | 57.00 ± 35.10 | 0.111# | 0.282# | <0.0001# | <0.0001# |
| Positive anti-Tg, n (%) | 12 (18.46%) | 21 (95.45%) | 20 (30.30%) | 9 (28.13%) | 0.1545^ | 0.3026^ | <0.0001^ | <0.0001^ |
| Anti-Dsg1, U/ml (mean ± SEM) | 116.06 ± 7.07 | 168.89 ± 19.31 | ||||||
| Anti-Dsg3, U/ml (mean ± SEM) | 136.22 ± 8.17 | 3.15 ± 0.56 |
PV, pemphigus vulgaris; PF, pemphigus foliaceus; TG, thyroglobulin; TPO, thyroid peroxidase.
Normal values: anti-TPO: 0-5.6100 IU/ml; anti-Tg: 0-4.1100 IU/ml; anti-Dsg1: 0-20 U/ml; anti-Dsg3: 0-20 U/ml.
#Mann-Whitney U-test.
^The Fisher’s exact test.