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. 2021 Mar 16;12:626342. doi: 10.3389/fphar.2021.626342

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Copyright © 2021 Cai, Ni, Han, Chen and Peng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic model representing the anti-rheumatoid arthritis (RA) effects of herbal medicinal products on therapeutic enzymes and their derivatives targets in RA. Additional abbreviations: 15-HETE: 15-hydroperoxy-eicosatetraenoic acid; COX-2: cyclooxygenase-2; PLA₂: phospholipase A₂; IDO: indoleamine 2, 3-dioxygenase; IFN-γ: interferon gamma; IL-1: interleukin-1; LTB4: leukotriene B4; LTC4: leukotrienes C4; LOX: lipoxygenase; MMP: matrix metalloproteinase; NOS: Nitric oxide synthase; NO: nitric oxide; PGE2: prostaglandin E2; Tan IIA: tanshinone IIA; TGP: total glycosides of paeony; TNF-α: tumor necrosis factor α; TXA2: thromboxane A2.