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. 2021 Mar 16;12:642541. doi: 10.3389/fmicb.2021.642541

Figure 2.

Figure 2

Effects of azithromycin on the peptidyl-tRNA drop-off and on the depletion of rare tRNAs isoacceptors. (A) Protein synthesis; (B) azithromycin (i) blocks the peptide exit channel of the 50S ribosomal subunit, inhibits bacterial protein translation, and causes premature detachment of incomplete peptide chains, (ii) leading to an increased peptidyl-tRNA drop-off, and (iii) resulting in a depletion of the intracellular pool of aminoacyl-tRNA. Rare tRNAs isoacceptors are the most affected.