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. 2021 Mar 5;24(4):102265. doi: 10.1016/j.isci.2021.102265

Figure 3.

Figure 3

Longitudinal assessment of systemic and tissue-specific insulin sensitivity in CD and HFD mice

(A) Blood glucose during ITT (0.75 U/kg insulin) (N ≥ 7 mice/group). The ratios of AUC for HFD versus CD are presented at the top of each graph.

(B) Hyperinsulinemic-euglycemic clamp tests (N ≥ 6 mice/group).

(C and D) Immunoblot (C) and quantification (D) of Akt (Ser473) phosphorylation status relative to total Akt and GSK-3α/β (Ser21/9) phosphorylation status relative to total GSK-3α/β in liver (N = 4–6 mice/group).

All data are expressed as mean ± SEM and analyzed using unpaired two-tailed t test. ∗p < 0.05, ∗∗p < 0.01. See also Figure S3.