Skip to main content
. 2021 Mar 29;4(3):e213526. doi: 10.1001/jamanetworkopen.2021.3526

Table 4. Associations Between Maternal Socioeconomic Measures and Brain Lobe Volumes and Cortical Featuresa.

Lobe volume, cm3 LGI × 10−3 Sulcal depth × 10−3 mm
β (95% CI) P value β (95% CI) P value β (95% CI) P value
Education level
Frontal lobe 0.91 (0.22 to 1.59) .01b −13 (−23 to −3) .01b −25 (−64 to 15) .22
Parietal lobe 0.90 (0.43 to 1.37) <.001b −29 (−45 to −14) <.001b −116 (−171 to −62) <.001b
Temporal lobe 0.54 (0.27 to 0.82) <.001b −18 (−30 to −6) .005b −62 (−105 to −18) .01b
Occipital lobe 0.23 (0.02 to 0.45) .03b −28 (−42 to −15) <.001b −94 (−136 to −53) <.001b
Occupation level
Frontal lobe 0.67 (0.16 to 1.17) .01b −10 (−17 to −3) .01b −22 (−52 to 7) .13
Parietal lobe 0.62 (0.27 to 0.97) .001b −22 (−33 to −10) <.001b −85 (−125 to −44) <.001b
Temporal lobe 0.38 (0.17 to 0.59) <.001b −13 (−22 to −4) .005b −48 (−81 to −16) .003b
Occipital lobe 0.17 (0.01 to 0.33) .04b −18 (−28 to −8) .001b −64 (−95 to −33) <.001b
SES score
Frontal lobe 0.07 (0.02 to 0.13) .01b −1.1 (−1.9 to −0.3) .01b −2.4 (−5.5 to 0.7) .14
Parietal lobe 0.07 (0.03 to 0.11) <.001b −2.4 (−3.6 to −1.2) <.001b −9.5 (−13.8 to −5.3) <.001b
Temporal lobe 0.04 (0.02 to 0.07) <.001b −1.5 (−2.4 to −0.5) .003b −5.3 (−8.7 to −1.9) .002b
Occipital lobe 0.02 (0.002 to 0.04) .03b −2.1 (−3.2 to −1.0) <.001b −7.3 (−10.6 to −4.1) <.001b

Abbreviations: GA, gestational age; LGI, local gyrification index; SES, socioeconomic status.

a

Adjusted for GA at magnetic resonance imaging scan (wk) and fetal sex (ie, female: 0; male: 1).

b

q < 0.05.