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. 2020 Jun 8;63(13):6834–6846. doi: 10.1021/acs.jmedchem.0c00208

Figure 2.

Figure 2

(a) Selected key compounds in the optimization campaign and respective TNKS2 and HEK293 IC50 values. Mean ± SD values for three independent experiments are shown. Moieties are in color when differing from 1. (b) ADME data of key compounds. (c) Cellular efficacy and mouse po PK 5 mg/kg of the short-listed compounds.