Table 1. m-Substituted Derivatives 1–10^a.

code	R	% residual activity	IC50 (μM)
1	3-CF3	42.0 ± 6.3
2	3-Cl	101.6 ± 17.8
3	3-OH	70.4 ± 21.8
4	3-CH3	103.9 ± 4.8
5	3-NH2	65.8 ± 9.6
6	3-CONH2	20.9 ± 4.3	31.4 ± 10.3
7	3-CONHCH3	84.0 ± 9.1
8	3-SO2NH2	28.6 ± 6.8
9	3-COOH	27.2 ± 4.5
10	3-CN	3.1 ± 1.0	6.3 ± 0.9

^aInhibitory effect is expressed as percentage of residual enzymatic activity (at 100 μM ligand concentration) for all compounds and half-maximal inhibitory concentrations (IC₅₀, μM) only for the most active candidates (residual activity ≤ 25%).