Figure 3.

Improved cold tolerance in Actn3 KO mice

(A) Survival plot of the time taken to reach 35.5°C core body temperature within 5 h exposure to 4°C air temperature in WT (n = 38, blue line) and Actn3 KO (n = 29, red line) mice. Log-rank (Mantel-COX) test was used to assess statistical difference between WT and KO mice.

(B and C) The rate of decline in rectal temperature and body weight of WT and Actn3 KO mice.

(D) The rectal temperature at the end of the 5 h of cold exposure plotted against the body weight.

Plots in (B)–(D) show values for each WT (blue squares) and Actn3 KO (red squares) mouse and mean ± SEM. Statistical differences between the two groups assessed with unpaired t test.