Figure 6.

Polygenic risk scores (PRSs) in African Americans and Europeans as a function of different discovery ancestry groups

PRSs in African Americans and UK Biobank individuals derived via 215 of the known disease SNPs and liability scale effects estimated from the African American discovery cohort (AA_liability, red) or the UK Biobank discovery cohort (UKBB_liability, green).

(A and B) Prevalence of IBD (%) versus percentile of PRS in each cohort.

(C and D) Mean proportion of variance explained (PVE) by each PRS. Standard error bars are from five test sets.