. Author manuscript; available in PMC: 2022 Feb 10.

Published in final edited form as: J Control Release. 2020 Nov 18;330:1229–1243. doi: 10.1016/j.jconrel.2020.11.029

Table 4.

IC₅₀ values for drug-loaded micelles and free drugs against normal hTERT-HPNE pancreatic cells.^a

Sample	Drug ratio, w/w	IC₅₀ (mM)
Sample	Drug ratio, w/w	48h	72h
IRIN	-	>500	>500
OX	-	0.7 ± 0.2	2.4 ± 0.6
IRIN + OX	2	0.5 ± 0.3	3.5 ± 1.4
SN38/m	-	>10	>10
SN38/m + OX	1	1.4 ± 0.5	3.1± 1.3
(SN38 + DACHPt)/m	1	>10	9.5 ± 2.7

Cells were seeded at the density of 3,000 cell/well and exposed to various drug formulations for 48h or 72h followed by culturing in fresh completed media for 24h. IC₅₀ values for drug combinations were calculated with respect to OX equivalents. Data are presented as mean ± SD (n = 3).