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. 2021 Mar 30;13:52. doi: 10.1186/s13073-021-00868-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Dissemination routes of E. faecium across the world. Worldwide dissemination of genomes belonging to cluster 2 (n = 122) analysed using spatial, temporal and genomic data through BEAST v2.6 and visualised using SpreaD3. Coloured nodes on the map represent an isolate’s country of origin (as shown in the legend), while connecting lines are coloured by destination location. An expanded view is shown in panel a to show inferred spread of E. faecium isolates across Europe with complex links between and within countries. b E. faecium dissemination across the globe with surrounding circle sizes proportional to the number of lineages (isolates that share the same continuous line of ancestry) that occur in that location and captures the absolute and relative intensity of the local spread at any given point in time