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. 2021 Mar 29;20:77. doi: 10.1186/s12934-021-01516-3

Table 1.

Overview of fermentation strategies involved in this review

Code Strategies Cultivation scale Process Time (h) Production References
1 Using antifoaming agent 5 l Fed-batch 260 240 g/l Bazsefidpar et al. [76]
5 l Fed-batch 120 70.56 g/l Zhu et al. [16]
50 l Batch 100 38.3 g/l Sha et al. [78]
2 Fermentation in weak acid condition 2 l Batch 217 42.1 g/l Sodagari et al. [11]
3 Foam fractionation fermentation 2.5 l Batch 16 0.85 g Beuker et al. [85]
2.5 l Batch 30 3.99 g/l (in foam) Willenbacher et al. [84]
10 l Batch Ahout 500 70 g Heyd et al. [80]
4 Foam adsorption fermentation 1.5 l Batch 42 42 g/l Zheng et al. [82]
5 Fermentation-defoaming tandem system 10 l fermenter with a 100 l foam collector Batch 72 30 g/l Long et al. [10]
300 l fermenter with a 300 l foam collector Batch 168 60 g/l Gong et al. [23]
2.5 l fermenter with a 0.5 l foam collector Fed-batch 240 8.06 g/l Salwa et al. [87]
6 Using Stop valve as a foam breaker 10 l fermenter with a 10 l foam collector Batch 96 About 40 g/l Long et al. [75]
7 Solidstate fermentation 30 l air pressure pulsation solid-state fermentation fermenter Batch 168 39.8 g/l Gong et al. [19]
250 ml Erlenmeyer flasks Batch 144 41.87 g/l El-Housseiny et al. [101]
250 ml Erlenmeyer flasks Batch 288 45.4 g/l Camilios-Neto et al. [61]
250 ml Erlenmeyer flasks Batch 288 46 g/l Neto et al. [93]
8 Semi-solid-state fermentation 250- ml Erlenmeyer flask Batch 288 18.7 g/l Wu et al. [95]
9 Anaerobic fermentation 6 l Batch 214 0.63 g/l Zhao et al. [97]
6 l Batch 220 1.08 g/l Zhao et al. [42]
6 l Batch 240 1.61 g/l Zhao et al. [98]
The extracapillary space of the hollow-fiber setup Circulate medium in the extracapillary space 1250 About 5 g/l Pinzon et al. [100]