Table 1.

Summary of the research works about the DNA methylation role in asthma-related genes and pathways

Author and year	Subjects	Specimen	Genes/regions	Phenotype	References
Kwon et al. 2008	Adults	Venous blood, cultured CD4 +	IL-4 and IFN-γ	Bronchial asthma	[33]
Breton et al. 2011	Children	Buccal cells	NOS1, NOS2A, NOS3, ARG1, and ARG2	Childhood asthma	[23]
Brand et al. 2012	Female BALB/c mice and BALB/$c^{\mathrm{scid}}$ mice	Blood	CNS1 and IFN-γ	Asthma	[32]
Baccarelli et al. 2012	Children	Nasal cell	IL-6 and iNOS	Childhood asthma	[24]
Verma et al. 2013	Balb/c mice	lung, trachea tissues and BALF cells and Whole blood	DNMT1, Socs3, STAT3, IFN-y, IL-4, IL-5 and IL-6	Asthma	[34]
Gagné-Ouellet et al. 2015	Adult and Children	Whole blood	IL1R1 and IL1R2	Asthma and atopy	[41]
Larouche et al. 2018	Adults	Bronchial epithelial cell line	CCL26 and IL-33	Asthma	[42]
Forno et al. 2019	Children	Nasal cells	30 CpG regions	Atopy and atopic asthma	[36]