Fig. 4.

Negative associations between plasma pTau181 and GM or WM volume progressed over time. a CU individuals showed GM degeneration 36 months after baseline, in the precuneus, medial frontal, anterior cingulate, and temporal lobe. b Similar regions were affected 48 months after baseline. c The CI group presented GM degeneration 12 months after baseline, in the medial frontal, precuneus, posterior cingulate, and temporal lobe. d At month 24, similar regions were affected spreading to the medial occipital cortex. e, f At months 36 and 48, it spread even further in the medial frontal, temporal, and posterior regions of the brain. g In the CI group, 12 months after baseline, there was a negative correlation between WM and plasma pTau181 in the temporal lobe. h At month 24, it started spreading to the corpus callosum. i At month 36, the WM tracts in the frontal and occipital lobe were affected. j At month 48, most of the WM in the brain seemed affected