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. 2021 Mar 29;18:83. doi: 10.1186/s12974-021-02134-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Microglial morphological phenotype does not determine cell elasticity. a Pie graphs indicating per condition the percentage of amoeboid and ramified indented microglia per brain area (WM derived = blue, GM derived = red). b Elasticity (storage modulus, upper graphs) and viscosity (loss modulus, lower graphs) of the microglia with an amoeboid or ramified phenotype derived from WM (blue) and GM (red). Black dots represent individual microglia measurements from N=6 independent cultures for control and LPS conditions and N=2 for myelin and myelin+LPS conditions. Bars represent the mean of all measurements per condition ± SEM. Representative immunocytochemical images of IBA-1 (green) in WM-derived microglia (c–f) and GM-derived microglia (g–j). Myelin phagocytosis is visualized by pHrodo (red, e, f, i, j). Arrows indicate phagocytosed myelin. Scalebar = 50 μm (c–j)